Acetyl-CoA Carboxylase
ACC, Acetyl Coenzyme A Carboxylase
Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.
In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).
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Acetyl-CoA Carboxylase Inhibitors
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Acetyl-CoA Carboxylase Agonist
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Acetyl-CoA Carboxylase Activators
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Acetyl-CoA Carboxylase Modulators
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Acetyl-CoA Carboxylase Degrader
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Acetyl-CoA Carboxylase Ligand
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Acetyl-CoA Carboxylase Related Products (92)
Related Products (92)
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Antibodies (5)
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QPP-I-6
0 ImagesCat. No.: HY-158246CAS No.: 2864442-05-5QPP-I-6 is an inhibitor for acetyl-coenzyme A carboxylase (ACCase). QPP-I-6 exhibits herbicidal activity through induction of cell membrane permeability.
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Metproxybicyclone
0 ImagesCat. No.: HY-185314CAS No.: 1848207-89-5Metproxybicyclone is a graminaceous herbicide. Metproxybicyclone also acts as an ACCase inhibitor, with an IC50 of 0.19 μM against Lolium multiflorum. Metproxybicyclone inhibits eukaryotic homomeric acetyl-CoA carboxylase, which catalyzes the first key step in fatty acid biosynthesis of graminaceous plants. Metproxybicyclone controls susceptible graminaceous weeds as well as graminaceous weed populations with target-site, non-target-site, and ACCaseD2078G target-site resistance mechanisms. Metproxybicyclone is safe to dicotyledonous crops and is suitable for pre-plant burndown applications.
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IRW
0 ImagesCat. No.: HY-P11358CAS No.: 159718-10-2IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation.
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AMPK activator 18
0 ImagesCat. No.: HY-115549CAS No.: 1364692-88-5AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform. AMPK activator 18activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, with EC50 values of 17.2 and 82.1 nM. AMPK activator 18 stimulates β2-AMPK in cells, and glucose uptake by isolated skeletal muscle. AMPK activator 18 induces acetyl-coenzyme A carboxylase (ACC) and AMPK α-T172 phosphorylation. AMPK activator 18 can be used for the research of type 2 diabetes.
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(+)-Allohydroxycitric acid calcium hydrate
0 ImagesCat. No.: HY-W716421ACAS No.: 355017-63-9(+)-Allohydroxycitric acid calcium hydrate is a weak acetyl-CoA carboxylase (ACC) activator with a Km of 20 mM. (+)-Allohydroxycitric acid calcium hydrate can replace citrate to activate ACC in vitro, but does not produce an in vivo agonistic effect in vivo. (+)-Allohydroxycitric acid calcium hydrate cannot alter the rates of hepatic fatty acid and cholesterol synthesis in rats, and has no lipid-regulating effect. (+)-Allohydroxycitric acid calcium hydrate can be used for metabolism-related research.
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PF-05221304 tromethamine
0 ImagesCat. No.: HY-137846ACAS No.: 2334472-62-5PF-05221304 tromethamine is an orally active, liver-directed and dual ACC1/ACC2 inhibitor with IC50s of 7.5 nM for rat ACC1, 8.2 nM for rat ACC2. PF-05221304 tromethamine is a substrate for organic anion transport polypeptides. PF-05221304 tromethamine directly improves a variety of non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) pathogenic factors.
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Fluazifop (Standard)
0 ImagesCat. No.: HY-121427RCAS No.: 69335-91-7Fluazifop (Standard) is the analytical standard of Fluazifop. This product is intended for research and analytical applications. Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase.
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Rhinacanthin C
0 ImagesCat. No.: HY-N15205CAS No.: 159278-74-7Rhinacanthin C is an orally active naphthoquinone ester and P-gp inhibitor (IC50 = 5.20 μM). Rhinacanthin C exerts effects in ameliorating hepatic steatosis, insulin resistance, and inflammation by inhibiting P-gp, BCRP, OATP1B1/1B3, and multiple CYP enzymes, downregulating lipid synthesis-related factors such as ACC and FAS, and upregulating AMPKα phosphorylation and SIRT1. Rhinacanthin C can be used in research on non-alcoholic fatty liver disease, diabetes, abnormal osteolysis, Alzheimer's disease, and inflammation.
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Fluazifop-d3
0 ImagesCat. No.: HY-121427S
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Haloxyfop-d4
0 ImagesCat. No.: HY-B1856SCAS No.: 127893-34-9Haloxyfop-d4 is deuterium labeled Haloxyfop. Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops. Haloxyfop inhibits the acetyl coenzyme A carboxylase (EC 6.4.1.2) from corn seedling chloroplasts with an IC50 of 0.5 μM, but has no effect on this enzyme in pea.
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Tralkoxydim (Standard)
0 ImagesCat. No.: HY-111223RCAS No.: 87820-88-0Synonyms: PP604 (Standard); ICIA 0604 (Standard); FD-4026 (Standard)Tralkoxydim (Standard) is the analytical standard of Tralkoxydim. This product is intended for research and analytical applications. Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn.
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ACC2-IN-1
0 ImagesCat. No.: HY-183919CAS No.: 2237229-78-4ACC2-IN-1 is an orally active, selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 of 1.9 nM against human targets. ACC2-IN-1 acts as a reducing agent to decrease malonyl-CoA levels in skeletal muscle and exhibits a favorable CYP450 inhibition profile. ACC2-IN-1 can be used in the research of type 2 diabetes.
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Diclofop
0 ImagesCat. No.: HY-121273CAS No.: 40843-25-2Synonyms: Dichlorfop acid; (±)-DiclofopDiclofop (Dichlorfop acid) is an acetyl-CoA carboxylase (ACC) inhibitor. Diclofop is also the major metabolite of the herbicide Diclofop-methyl (HY-136367). Diclofop exhibits antimalarial activity with an IC50 of 210 μM against P. falciparum.
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Quizalofop-P (Standard)
0 ImagesCat. No.: HY-117142RCAS No.: 94051-08-8Quizalofop-P (Standard) is the analytical standard of Quizalofop-P. This product is intended for research and analytical applications. Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops.
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Haloxyfop (Standard)
0 ImagesCat. No.: HY-B1856RCAS No.: 69806-34-4Haloxyfop (Standard) is the analytical standard of Haloxyfop. This product is intended for research and analytical applications. Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops. Haloxyfop inhibits the acetyl coenzyme A carboxylase (EC 6.4.1.2) from corn seedling chloroplasts with an IC50 of 0.5 μM, but has no effect on this enzyme in pea.
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MK-4074 (Standard)
0 ImagesCat. No.: HY-107709RCAS No.: 1039758-22-9MK-4074 (Standard) is the analytical standard of MK-4074 (HY-107709). This product is intended for research and analytical applications. MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM.
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Sethoxydim (Standard)
0 ImagesCat. No.: HY-135753RCAS No.: 74051-80-2Synonyms: BAS 9052 (Standard)Sethoxydim (Standard) is the analytical standard of Sethoxydim. This product is intended for research and analytical applications. Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity.
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AMPK activator 16
0 ImagesCat. No.: HY-170931CAS No.: 2252336-04-0AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells.
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Fluazifop-P-butyl (Standard)
0 ImagesCat. No.: HY-B2007RCAS No.: 79241-46-6Fluazifop-P-butyl (Standard) is the analytical standard of Fluazifop-P-butyl (HY-B2007). This product is intended for research and analytical applications. Fluazifop-P-butyl is an orally active herbicide and ACCase inhibitor. Fluazifop-P-butyl blocks the formation of malonyl-CoA, disrupts lipid synthesis in sensitive plants, and exhibits concentration-dependent phytotoxicity to non-target maize seedlings. Fluazifop-P-butyl induces oxidative stress in male Wistar rats, impairs their liver and kidney functions, and disrupts testicular function.
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Spiromesifen (Standard)
0 ImagesCat. No.: HY-114591RCAS No.: 283594-90-1Synonyms: BSN 2060 (Standard)Spiromesifen (Standard) is the analytical standard of Spiromesifen. Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase, and has no cross-resistance to any resistant mite or whitefly populations.
